Heavy smoking in middle age appears to be associated with more than double the risk for Alzheimer's disease and other forms of dementia two decades later, according to a report posted online that will be published in the February 28 print issue of Archives of Internal Medicine, one of the JAMA/Archives journals.
Current estimates suggest smoking is responsible for several million deaths per year from causes such as heart disease and cancer, according to background information in the article. Although smoking increases risks of most diseases and of death, some studies have shown a reduced risk of Parkinson's disease and other neurodegenerative conditions among smokers. "The link between smoking and risk of Alzheimer's disease, the most common subtype of dementia, has been somewhat controversial, with some studies suggesting that smoking reduces the risk of cognitive impairment," the authors write.